Pravastatin for Primary Prevention in Older Adults: Restricted Mean Survival Time Analysis.

ABSTRACT:

Objectives

To use restricted mean survival time, which summarizes treatment effects in terms of event-free time over a fixed time period, to evaluate the benefit of pravastatin therapy for primary prevention of cardiovascular disease in older adults.

Design

Secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial-Lipid-Lowering Trial (ALLHAT-LLT).

Setting

Ambulatory setting.

Participants

Individuals aged 65 and older (mean aged 71, 49% female) free of cardiovascular disease (N=2,867).

Intervention

Pravastatin 40 mg/d (n=1,467) versus usual care (n=1,400).

Measurements

We estimated the difference in RMST for total and coronary heart disease (CHD)-free survival between the pravastatin and usual care group

SUBMITTER: Orkaby AR 

PROVIDER: S-EPMC6181782 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature