Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC6181972 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181011 1
Skatole is a malodorous compound that contributes to the characteristic smell of animal faeces. Although skatole has long been known to originate from bacterial tryptophan fermentation, the enzyme catalysing its formation has so far remained elusive. Here we report the use of comparative genomics for the discovery of indoleacetate decarboxylase, an O<sub>2</sub>-sensitive glycyl radical enzyme catalysing the decarboxylation of indoleacetate to form skatole as the terminal step of tryptophan ferm ...[more]