Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters.

ABSTRACT: Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of

SUBMITTER: de Lorgeril J 

PROVIDER: S-EPMC6182001 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature