Three Antifungal Proteins From <i>Penicillium expansum</i>: Different Patterns of Production and Antifungal Activity.

ABSTRACT: Antifungal proteins of fungal origin (AFPs) are small, secreted, cationic, and cysteine-rich proteins. Filamentous fungi encode a wide repertoire of AFPs belonging to different phylogenetic classes, which offer a great potential to develop new antifungals for the control of pathogenic fungi. The fungus Penicillium expansum is one of the few reported to encode three AFPs each belonging to a different phylogenetic class (A, B, and C). In this work, the production of the putative AFPs from P. expansum was evaluated, but only the representative of class A, PeAfpA, was identified in culture supernatants of the native fungus. The biotechnological production of PeAfpB and PeAfpC was achieved in Penicillium chrysogenum with the P. chrysogenum-based expression cassette,

SUBMITTER: Garrigues S 

PROVIDER: S-EPMC6182064 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature