Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study.

ABSTRACT: Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patterns of ¹⁸F-THK5351 and resting state network (RSN) disruption in patients with early AD and healthy controls. Methods: We enrolled 23 ¹¹C-Pittsburgh compound B (PiB)-positive patients with early AD and 24 ¹¹C-PiB-negative participants as healthy controls. All participants underwent resting state functional MRI and ¹⁸F-THK5351 PET scans. We used scaled subprofile modeling/principal component analysis (SSM/PCA) to reduce the complexity of multivariate data and to identify patterns that exhi

SUBMITTER: Yokoi T 

PROVIDER: S-EPMC6182068 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature