Comparing Adult Hippocampal Neurogenesis Across Species: Translating Time to Predict the Tempo in Humans.

ABSTRACT: Comparison of neurodevelopmental sequences between species whose initial period of brain organization may vary from 100 days to 1,000 days, and whose progress is intrinsically non-linear presents large challenges in normalization. Comparing adult timelines when lifespans stretch from 1 year to 75 years, when underlying cellular mechanisms under scrutiny do not scale similarly, presents challenges to simple detection and comparison. The question of adult hippocampal neurogenesis has generated numerous controversies regarding its simple presence or absence in humans versus rodents, whether it is best described as the tail of a distribution centered on early neural development, or is several distinct processes. In addition, adult neurogenesis may have substantially changed in evolutionary tim

SUBMITTER: Charvet CJ 

PROVIDER: S-EPMC6182078 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature