Independent erosion of conserved transcription factor binding sites points to shared hindlimb, vision and external testes loss in different mammals.

ABSTRACT: Genetic variation in cis-regulatory elements is thought to be a major driving force in morphological and physiological changes. However, identifying transcription factor binding events that code for complex traits remains a challenge, motivating novel means of detecting putatively important binding events. Using a curated set of 1154 high-quality transcription factor motifs, we demonstrate that independently eroded binding sites are enriched for independently lost traits in three distinct pairs of placental mammals. We show that these independently eroded events pinpoint the loss of hindlimbs in dolphin and manatee, degradation of vision in naked mole-rat and star-nosed mole, and the loss of external testes in white rhinoceros and Weddell seal. We additionally show that our method may also

SUBMITTER: Berger MJ 

PROVIDER: S-EPMC6182171 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature