Accurate Coil Positioning is Important for Single and Paired Pulse TMS on the Subject Level.

ABSTRACT: Function-guided navigation is commonly used when assessing cortical excitability using transcranial magnetic stimulation (TMS). However, the required accuracy, stability and the effect of a change in coil positioning are not entirely known. This study investigates the accuracy of function-guided navigation for determining the hotspot. Furthermore, it evaluates the effect of a change in coil location on the single and paired pulse excitability measures: motor evoked potential (MEP) amplitude, TMS evoked potential (TEP) and long intracortical inhibition (LICI), and of a change in coil orientation on LICI. Eight healthy subjects participated in the single pulse study, and ten in the paired pulse study. A robot-guided navigation system was used to ensure accurate and stable coil positioning at

SUBMITTER: de Goede AA 

PROVIDER: S-EPMC6182440 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature