Effects of N-acetylcysteine on brain glutamate levels and resting perfusion in schizophrenia.

ABSTRACT:

Rationale

N-Acetylcysteine (NAC) is currently under investigation as an adjunctive treatment for schizophrenia. The therapeutic potential of NAC may involve modulation of brain glutamate function, but its effects on brain glutamate levels in schizophrenia have not been evaluated.

Objectives

The aim of this study was to examine whether a single dose of NAC can alter brain glutamate levels. A secondary aim was to characterise its effects on regional brain perfusion.

Methods

In a double-blind placebo-controlled crossover study, 19 patients with a diagnosis of schizophrenia underwent two MRI scans, following oral administration of 2400 mg NAC or matching placebo. Proton magnetic resonance spectroscopy was used to investigate the effect of NAC on glutamate and Glx (glutama

SUBMITTER: McQueen G 

PROVIDER: S-EPMC6182588 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature