Dopamine, time perception, and future time perspective.

ABSTRACT:

Rationale

Impairment in time perception, a critical component of decision-making, represents a risk factor for psychiatric conditions including substance abuse. A therapeutic that ameliorates this impairment could be advantageous in the treatment of impulsivity and decision-making disorders.

Objectives

Here we hypothesize that the catechol-O-methyltransferase (COMT) inhibitor tolcapone, which increases dopamine tone in frontal cortex (Ceravolo et al Synapse 43:201-207, 2002), improves time perception, with predictive behavioral, genetic, and neurobiological components.

Methods

Subjects (n = 66) completed a duration estimation task and other behavioral testing in each of two sessions after receiving a single oral dose of tolcapone (200 mg) or placebo in randomized, dou

SUBMITTER: Mitchell JM 

PROVIDER: S-EPMC6182591 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature