Dual contributions of noradrenaline to behavioural flexibility and motivation.

ABSTRACT:

Introduction

While several theories have highlighted the importance of the noradrenergic system for behavioral flexibility, a number of recent studies have also shown a role for noradrenaline in motivation, particularly in effort processing. Here, we designed a novel sequential cost/benefit decision task to test the causal influence of noradrenaline on these two functions in rhesus monkeys.

Methods

We manipulated noradrenaline using clonidine, an alpha-2 noradrenergic receptor agonist, which reduces central noradrenaline levels and examined how this manipulation influenced performance on the task.

Results

Clonidine had two specific and distinct effects: first, it decreased choice variability, without affecting the cost/benefit trade-off; and second, it reduced force p

SUBMITTER: Jahn CI 

PROVIDER: S-EPMC6182595 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature