Novel Imaging Biomarkers for Huntington's Disease and Other Hereditary Choreas.

ABSTRACT:

Purpose of the review

Imaging biomarkers for neurodegenerative disorders are primarily developed with the goal to aid diagnosis, to monitor disease progression, and to assess the efficacy of disease-modifying therapies in support to clinical outcomes that may either show limited sensitivity or need extended time for their evaluation. This article will review the most recent concepts and findings in the field of neuroimaging applied to Huntington's disease and Huntington-like syndromes. Emphasis will be given to the discussion of potential pharmacodynamic biomarkers for clinical trials in Huntington's disease (HD) and of neuroimaging tools that can be used as diagnostic biomarkers in HD-like syndromes.

Recent findings

Several magnetic resonance (MR) and positron emission tomo

SUBMITTER: Fazio P 

PROVIDER: S-EPMC6182636 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature