Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men.

ABSTRACT:

Purpose

Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case-control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and lifestyle factors.

Methods

The study population consisted of 1010 cases occurring during a mean follow-up of 14.6 years, and 1817 controls matched on age and study entry date. We used national registers (95%) and hospital records (5%) to ascertain cases. Diet was estimated by a modified diet history method. Plasma ENL concentrations were determined by a time-resolved fluoroimmunoassay.

SUBMITTER: Wallstrom P 

PROVIDER: S-EPMC6182673 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature