Neurodegeneration-associated FUS is a novel regulator of circadian gene expression.

ABSTRACT:

Background

Circadian rhythms are oscillating physiological and behavioral changes governed by an internal molecular clock, and dysfunctions in circadian rhythms have been associated with ageing and various neurodegenerative diseases. However, the evidence directly connecting the neurodegeneration-associated proteins to circadian control at the molecular level remains sparse.

Methods

Using meta-analysis, synchronized animals and cell lines, cells and tissues from FUS R521C knock-in rats, we examined the role of FUS in circadian gene expression regulation.

Results

We found that FUS, an oscillating expressed nuclear protein implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), exerted a novel feedback route to regulate c

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6182827 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature