Economic impact of screening for X-linked Adrenoleukodystrophy within a newborn blood spot screening programme.

ABSTRACT:

Background

A decision tree model was built to estimate the economic impact of introducing screening for X-linked adrenoleukodystrophy (X-ALD) into an existing tandem mass spectrometry based newborn screening programme. The model was based upon the UK National Health Service (NHS) Newborn Blood Spot Screening Programme and a public service perspective was used with a lifetime horizon. The model structure and parameterisation were based upon literature reviews and expert clinical judgment. Outcomes included health, social care and education costs and quality adjusted life years (QALYs). The model assessed screening of boys only and evaluated the impact of improved outcomes from hematopoietic stem cell transplantation in patients with cerebral childhood X-ALD (CCALD). Threshold analys

SUBMITTER: Bessey A 

PROVIDER: S-EPMC6182830 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature