Integrating omics datasets with the OmicsPLS package.

ABSTRACT:

Background

With the exponential growth in available biomedical data, there is a need for data integration methods that can extract information about relationships between the data sets. However, these data sets might have very different characteristics. For interpretable results, data-specific variation needs to be quantified. For this task, Two-way Orthogonal Partial Least Squares (O2PLS) has been proposed. To facilitate application and development of the methodology, free and open-source software is required. However, this is not the case with O2PLS.

Results

We introduce OmicsPLS, an open-source implementation of the O2PLS method in R. It can handle both low- and high-dimensional datasets efficiently. Generic methods for inspecting and visualizing results are implemented.

SUBMITTER: Bouhaddani SE 

PROVIDER: S-EPMC6182835 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature