A Subset of CXCR5⁺CD8⁺ T Cells in the Germinal Centers From Human Tonsils and Lymph Nodes Help B Cells Produce Immunoglobulins.

ABSTRACT: Recent studies indicated that CXCR5⁺CD8⁺ T cells in lymph nodes could eradicate virus-infected target cells. However, in the current study we found that a subset of CXCR5⁺CD8⁺ T cells in the germinal centers from human tonsils or lymph nodes are predominately memory cells that express CD45RO and CD27. The involvement of CXCR5⁺CD8⁺ T cells in humoral immune responses is suggested by their localization in B cell follicles and by the concomitant expression of costimulatory molecules, including CD40L and ICOS after activation. In addition, CXCR5⁺CD8⁺ memory T cells produced significantly higher levels of IL-21, IFN-γ, and IL-4 at mRNA and protein levels compared to CXCR5^-CD8⁺ memory T

SUBMITTER: Shen J 

PROVIDER: S-EPMC6183281 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature