Validation of an Objective Measure of Dry Eye Severity.

ABSTRACT:

Purpose

We evaluated the validity of a single dry eye severity measure estimated using Rasch analysis from a battery of clinical tests and patient symptoms.

Methods

This study included 203 dry eye patients and 51 controls. Administered tests included the Ocular Surface Disease Index (OSDI), tear osmolarity, Schirmer's test, noninvasive break-up time, and ocular surface staining. Each of the 12 OSDI questions and each clinical test was defined to be a separate indicator to estimate a single dry eye severity measure from Rasch analysis. Measures of severity were estimated for each subject (person measures) and measures of sensitivity to severity were estimated for each sign and symptom (indicator measures).

Results

The average severity measure for dry eye patients was s

SUBMITTER: Karakus S 

PROVIDER: S-EPMC6183328 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature