Rapid evolution of generalized resistance mechanisms can constrain the efficacy of phage-antibiotic treatments.

ABSTRACT: Antimicrobial resistance has been estimated to be responsible for over 700,000 deaths per year; therefore, new antimicrobial therapies are urgently needed. One way to increase the efficiency of antibiotics is to use them in combination with bacteria-specific parasitic viruses, phages, which have been shown to exert additive or synergistic effects in controlling bacteria. However, it is still unclear to what extent these combinatory effects are limited by rapid evolution of resistance, especially when the pathogen grows as biofilm on surfaces typical for many persistent and chronic infections. To study this, we used a microcosm system, where genetically isogenic populations of Pseudomonas aeruginosa PAO1 bacterial pathogen were exposed to a phage 14/1, gentamycin or a combination of

SUBMITTER: Moulton-Brown CE 

PROVIDER: S-EPMC6183449 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature