Molecular characterization of papillary thyroid carcinoma: a potential three-lncRNA prognostic signature.

ABSTRACT:

Purpose

Papillary thyroid carcinoma (PTC), the most frequent type of malignant thyroid tumor, lacks novel and reliable biomarkers of patients' prognosis. In the current study, we mined The Cancer Genome Atlas (TCGA) to develop lncRNA signature of PTC.

Patients and methods

The intersection of PTC lncRNAs was obtained from the TCGA database using integrative computational method. By the univariate and multivariate Cox analysis, key lncRNAs were identified to construct the prognostic model. Then, all patients were divided into the high-risk group and low-risk group to perform the Kaplan-Meier (K-M) survival curves and time-dependent receiver operating characteristic (ROC) curve, estimating the prognostic power of the prognostic model. Functional enrichment analysis was also per

SUBMITTER: You X 

PROVIDER: S-EPMC6183593 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature