TBXA2R gene variants associated with bleeding.
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ABSTRACT:
SUBMITTER: Mundell SJ
PROVIDER: S-EPMC6183927 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
TBXA2R gene variants associated with bleeding.
Mundell Stuart James SJ Mumford Andrew A
Platelets 20180808 7
Platelet activity is regulated by a number of surface expressed G protein-coupled receptors (GPCRs) including the α isoform of the thromboxane receptor (TPα receptor). With the advance of genomic technologies, there has been a substantial increase in the identification of naturally occurring rare GPCR variants including in the TBXA2R gene, which encodes the TPα receptor. The study of patients with naturally occurring variants within TBXA2R associated with bleeding and abnormal TPα receptor funct ...[more]
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