ProteomeVis: a web app for exploration of protein properties from structure to sequence evolution across organisms' proteomes.

ABSTRACT: Motivation:Protein evolution spans time scales and its effects span the length of an organism. A web app named ProteomeVis is developed to provide a comprehensive view of protein evolution in the Saccharomyces cerevisiae and Escherichia coli proteomes. ProteomeVis interactively creates protein chain graphs, where edges between nodes represent structure and sequence similarities within user-defined ranges, to study the long time scale effects of protein structure evolution. The short time scale effects of protein sequence evolution are studied by sequence evolutionary rate (ER) correlation analyses with protein properties that span from the molecular to the organismal level. Results:We demonstrate the utility and versatility of ProteomeVis by investigating the distribution of edges per node

SUBMITTER: Razban RM 

PROVIDER: S-EPMC6184454 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature