REGGAE: a novel approach for the identification of key transcriptional regulators.

ABSTRACT:

Motivation

Transcriptional regulators play a major role in most biological processes. Alterations in their activities are associated with a variety of diseases and in particular with tumor development and progression. Hence, it is important to assess the effects of deregulated regulators on pathological processes.

Results

Here, we present REGulator-Gene Association Enrichment (REGGAE), a novel method for the identification of key transcriptional regulators that have a significant effect on the expression of a given set of genes, e.g. genes that are differentially expressed between two sample groups. REGGAE uses a Kolmogorov-Smirnov-like test statistic that implicitly combines associations between regulators and their target genes with an enrichment approach to prioritize the

SUBMITTER: Kehl T 

PROVIDER: S-EPMC6184769 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature