Wide-field multiphoton imaging through scattering media without correction.

ABSTRACT: Optical approaches to fluorescent, spectroscopic, and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances across the biomedical sciences. While the advances have been startling, the key unmet challenge to date in all forms of optical imaging is to penetrate deeper. A number of schemes implement aberration correction or the use of complex photonics to address this need. In contrast, we approach this challenge by implementing a scheme that requires no a priori information about the medium nor its properties. Exploiting temporal focusing and single-pixel detection in our innovative scheme, we obtain wide-field two-photon images through various turbid media including a scatterin

SUBMITTER: Escobet-Montalban A 

PROVIDER: S-EPMC6184782 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature