Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes.

ABSTRACT:

Objectives

Intracranial pressure in traumatic brain injury is dynamic and influenced by factors like injury patterns, treatments, and genetics. Existing studies use time invariant summary intracranial pressure measures thus potentially losing critical information about temporal trends. We identified longitudinal intracranial pressure trajectories in severe traumatic brain injury and evaluated whether they predicted outcome. We further interrogated the model to explore whether ABCC8 polymorphisms (a known cerebraledema regulator) differed across trajectory groups.

Design

Prospective observational cohort.

Setting

Single-center academic medical center.

Patients

Four-hundred four severe traumatic brain injury patients.

Interventions

None.

Measurements and

SUBMITTER: Jha RM 

PROVIDER: S-EPMC6185785 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature