Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.

ABSTRACT: BACKGROUND:Parkinsonisms are neurodegenerative disorders characterized pathologically by α-synuclein-positive (e.g., PD, diffuse Lewy body disease, and MSA) and/or tau-positive (e.g., PSP, cortical basal degeneration) pathology. Using R2* and quantitative susceptibility mapping, susceptibility changes have been reported in the midbrain of living parkinsonian patients, although the exact underlying pathology of these alterations is unknown. OBJECTIVE:The current study investigated the pathological correlates of these susceptibility MRI measures. METHODS:In vivo MRIs (T1- and T2-weighted, and T2*) and pathology were obtained from 14 subjects enrolled in an NINDS PD Biomarker Program (PDBP). We assessed R2* and quantitative susceptibility mapping values in the SN, semiquantitative α-synuclein

SUBMITTER: Lewis MM 

PROVIDER: S-EPMC6185787 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature