Gut microbiota in adolescents and the association with fatty liver: the EPOCH study.

ABSTRACT: BACKGROUND:Recent evidence supports that the gut microbiota may be involved in the pathophysiology of non-alcoholic fatty liver disease (NAFLD), and may also offer avenues for treatment or prevention. METHODS:We investigated the associations among gut microbiota, diet, and hepatic fat fraction (HFF) in 107 adolescents. Magnetic resonance imaging (MRI) was used to assess HFF, and 16S rRNA gene sequencing was performed on collected fecal samples. Dietary intake was assessed using Food Frequency Questionnaires. We examined the association between gut microbiota alpha diversity and HFF, and assessed the predictive accuracy for HFF of (1) taxonomic composition, (2) dietary intake, (3) demographic and comorbid conditions, and (4) the combination of these. RESULTS:Lower alpha diversity was associ

SUBMITTER: Stanislawski MA 

PROVIDER: S-EPMC6185796 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature