Repetitive transcranial magnetic stimulation for the treatment of Alzheimer's disease: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Several studies have demonstrated that repetitive transcranial magnetic stimulation (rTMS) may have a beneficial effect in Alzheimer's disease (AD). Nevertheless, the clinical benefit of rTMS for AD remains inconclusive.

Objective

This systematic review and meta-analysis aimed to evaluate the efficacy and safety of rTMS in AD.

Methods

We searched PubMed, Embase and Cochrane for randomized controlled trials (RCTs) of rTMS for AD. We calculated pooled estimates of mean difference (MD) with 95% confidence intervals (CI). The protocol was registered at International Prospective Register of Systematic Reviews (PROSPERO) (number CRD42018089990).

Results

Five RCTs involving 148 participants were included in this review. Compared with sham stimulation, high-

SUBMITTER: Dong X 

PROVIDER: S-EPMC6185837 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature