HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth.

ABSTRACT: Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine development. HIV superinfection (re-infection with a second strain following an established infection) has been associated with neutralization breadth, and can provide insights into how the immune system responds to sequential exposure to distinct HIV envelope glycoproteins (Env). Characterizing the neutralizing antibody (nAb) responses in four superinfected women revealed that superinfection does not boost memory nAb responses primed by the first infection or promote nAb responses to epitopes conserved in both infecting viruses. While one superinfected individual developed potent bnAbs, superinfection was likely not the driver as the

SUBMITTER: Sheward DJ 

PROVIDER: S-EPMC6185870 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature