A 627K variant in the PB2 protein of H9 subtype influenza virus in wild birds.

ABSTRACT:

Background

Wild birds are gaining increasing attention as gene-mixing reservoirs for influenza viruses. To investigate the molecular properties of the viruses isolated and epidemiological analysis of H9N2 subtype AIV in wild birds, we studied samples obtained over two years (2014-2015) from wetlands in Anhui province, China.

Methods

A total of 4534 samples were collected from migratory waterfowl in Anhui in 2014-2015, and 8 strains of H9 subtype AIV were isolated.

Results

Phylogenetic analysis showed different degrees of gene segment reassortment in H9 viruses between the Eurasian lineage and the North American lineage. Most importantly, two viruses harbored the E627K mutation in the polymerase PB2 (PB2) protein. This is the first report of the mutation of this virus

SUBMITTER: Ge Y 

PROVIDER: S-EPMC6185888 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature