Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree.

ABSTRACT: Bipolar disorder (BD) is a mental disorder characterized by alternating periods of depression and mania. Individuals with BD have higher levels of early mortality than the general population, and a substantial proportion of this is due to increased risk for comorbid diseases. To identify the molecular events that underlie BD and related medical comorbidities, we generated imputed whole-genome sequence data using a population-specific reference panel for an extended multigenerational Old Order Amish pedigree (n = 394), segregating BD and related disorders. First, we investigated all putative disease-causing variants at known Mendelian disease loci present in this pedigree. Second, we performed genomic profiling using polygenic risk scores (PRS) to establish each individual's risk for severa

SUBMITTER: Kember RL 

PROVIDER: S-EPMC6185949 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature