Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition.

ABSTRACT: Maternal overnutrition has been associated with increased susceptibility to develop obesity and neurological disorders later in life. Most epidemiological as well as experimental studies have focused on the metabolic consequences across generations following an early developmental nutritional insult. Recently, it has been shown that maternal high-fat diet (HFD) affects third-generation female body mass via the paternal lineage. We showed here that the offspring born to HFD ancestors displayed addictive-like behaviors as well as obesity and insulin resistance up to the third generation in the absence of any further exposure to HFD. These findings, implicate that the male germ line is a major player in transferring phenotypic traits. These behavioral and physiological alterations were parall

SUBMITTER: Sarker G 

PROVIDER: S-EPMC6185972 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature