Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.

ABSTRACT:

Background

Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.

Methods

We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.

Results

For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per

SUBMITTER: Ong JS 

PROVIDER: S-EPMC6186013 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature