Polymer coated gold-ferric oxide superparamagnetic nanoparticles for theranostic applications.

ABSTRACT:

Background

Engineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-L-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and the internalization of the NPs toward living mammalian cells is profoundly affected.

Methods

A

SUBMITTER: Abedin MR 

PROVIDER: S-EPMC6186064 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature