P53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification.

ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause DNA damage leading to cell death. Recent discoveries have highlighted a potential role for the p53 tumor suppressor in this disease. Given the pivotal role of p53 in the DNA damage response, here we investigated the predictive power of the p53 interactome model for MPM patients' stratification.

Methods

We used bioinformatics approaches including omics type analysis of data from MPM cells and from MPM patients in order to predict which pathways are crucial for patients' survival. Analysis of the PKT206 model of the p53 network was validated by microarrays from

SUBMITTER: Tian K 

PROVIDER: S-EPMC6186085 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature