Knockdown of RAI14 suppresses the progression of gastric cancer.

ABSTRACT:

Background

Retinoic acid induced 14 (RAI14), also known as NORPEG, is reported as being deregulated in non-small-cell lung cancer, together with having involvement in its cell proliferation as a super enhancer related gene.

Purpose

The objective of this study was to investigate the role of RAI14 in the progression and metastasis of gastric cancer and explore the associated mechanism.

Materials and methods

GEPIA database was used to analyze the expression of RAI14 in gastric cancer. MNK45 and AGS cells were transfected with siRNA-RAI14 to block the expression of RAI14. Cell Counting Kit 8 and colony formation assays were performed to measure cell proliferation. Cell migration and invasion capacities was examined by transwell as

SUBMITTER: Chen C 

PROVIDER: S-EPMC6186306 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature