A New Model of Diarrhea with Spleen-Kidney Yang Deficiency Syndrome.

ABSTRACT:

Objective

The aim of this study was to examine a new method to create a rat model of diarrhea with spleen-kidney yang deficiency syndrome.

Methods

A senna leaf (Folium sennae) decoction was made in 3 concentrations of 1.0, 0.5, and 0.25 g/mL. Rats were randomly divided into 4 groups: the control (C)-, high (H)-, middle (M)-, and low (L)- dose groups. The groups received saline, 1.0, 0.5, or 0.25 g/mL senna leaf decoction, respectively, for 4 weeks. Body weight monitoring, food consumption, water intake, defecation frequency, stool Bristol score, weight-loaded forced swimming test, forelimb grip strength test, D-xylose absorption test, serum cortisone, adrenocorticotropic hormone (ACTH), 24 h urine 17-hydroxycorticosteroid (17-OHCS), and histopathological detection were condu

SUBMITTER: Zhu J 

PROVIDER: S-EPMC6186382 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature