Effects of rheumatoid arthritis associated transcriptional changes on osteoclast differentiation network in the synovium.

ABSTRACT:

Background

Osteoclast differentiation in the inflamed synovium of rheumatoid arthritis (RA) affected joints leads to the formation of bone lesions. Reconstruction and analysis of protein interaction networks underlying specific disease phenotypes are essential for designing therapeutic interventions. In this study, we have created a network that captures signal flow leading to osteoclast differentiation. Based on transcriptome analysis, we have indicated the potential mechanisms responsible for the phenotype in the RA affected synovium.

Method

We collected information on gene expression, pathways and protein interactions related to RA from literature and databases namely Gene Expression Omnibus, Kyoto Encyclopedia of Genes and Genomes pathway and STRING. Based on these infor

SUBMITTER: Harshan S 

PROVIDER: S-EPMC6186409 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature