Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.

ABSTRACT:

Background

Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine pancreatic neoplasms with genotype and phenotype association to facilitate identification of prognostic and/or predictive biomarkers and examine potential therapeutic implications.

Methods

Six hundred fifteen unselected patients with exocrine pancreatic neoplasms were prospectively consented for somatic tumor and matched sample profiling for 410-468 genes. GT for PGAs in 76 genes associated with cancer susceptibility was performed in an "identified" manner in 356 (57.9%) patients and in an "anonymized" manner in 259 (42.1%) pati

SUBMITTER: Lowery MA 

PROVIDER: S-EPMC6186514 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature