Decreased plasma C-reactive protein levels in APOE ε4 allele carriers.

ABSTRACT:

Objective

Apolipoprotein E (APOE) ε4 allele is a well-established risk factor in Alzheimer's disease (AD). Here, we assessed the effects of APOE polymorphism on cardiovascular, metabolic, and inflammation-related parameters in population-based cohorts.

Methods

Association of cardiovascular, metabolic, and inflammation-related parameters with the APOE polymorphism in a large Finnish Metabolic Syndrome in Men (METSIM) cohort and Finnish Geriatric Intervention study to prevent cognitive impairment and disability (FINGER) were investigated. Brain-specific effects were addressed in postmortem brain samples.

Results

Individuals carrying the APOE ε4 allele displayed significantly elevated serum/plasma LDL cholesterol and apolipoprotein B le

SUBMITTER: Martiskainen H 

PROVIDER: S-EPMC6186931 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature