Heterogeneity in association of remote herpesvirus infections and pediatric MS.

ABSTRACT:

Objective

While prior Epstein-Barr virus (EBV) infection has been consistently associated with subsequent risk of developing multiple sclerosis (MS), the association with other common herpesviruses has been more controversial. Our objectives were to determine whether remote infection with EBV and other common herpesviruses affect the susceptibility to pediatric MS and if there are interactions between genetic and demographic factors and viral infections.

Methods

Cases with pediatric-onset MS or clinically isolated syndrome within 4 years of disease onset, and controls were recruited from 16 American pediatric MS centers. Logistic regression models adjusted for potential confounders assessed the association between case status and serological evidence for past infection with

SUBMITTER: Nourbakhsh B 

PROVIDER: S-EPMC6186938 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature