G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis.
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ABSTRACT:
SUBMITTER: Tomescu-Baciu A
PROVIDER: S-EPMC6186941 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis.
Tomescu-Baciu Alina A Vartdal Frode F Holmøy Trygve T Vedeler Christian A CA Lossius Andreas A
Annals of clinical and translational neurology 20180917 10
We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized va ...[more]
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