Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.

ABSTRACT:

Objective

The prognostic value of cerebrospinal fluid neurofilament light chain, total tau, phosphorylated tau₁₈₁, and amyloid beta_1-42 was examined in frontotemporal dementia subtypes.

Methods

We compared baseline biomarkers between 49 controls, 40 patients with behavioral variant frontotemporal dementia, 24 with semantic variant primary progressive aphasia, and 26 with nonfluent variant primary progressive aphasia. Linear mixed effect models were used to assess the value of baseline biomarkers in predicting clinical and radiographic change in patient cohorts over multiple yearly follow up visits.

Results

Neurofilament light chain concentrations were lowest in controls. Elevated baseline neurofilament light chain predicted faster worsening in cl

SUBMITTER: Ljubenkov PA 

PROVIDER: S-EPMC6186942 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature