Novel Combinations of Agents Targeting Translation That Synergistically Inhibit Fungal Pathogens.

ABSTRACT: A range of fungicides or antifungals are currently deployed to control fungi in agriculture or medicine, but resistance to current agents is growing so new approaches and molecular targets are urgently needed. Recently, different aminoglycoside antibiotics combined with particular transport inhibitors were found to produce strong, synergistic growth-inhibition of fungi, by synergistically increasing the error rate of mRNA translation. Here, focusing on translation fidelity as a novel target for combinatorial antifungal treatment, we tested the hypothesis that alternative combinations of agents known to affect the availability of functional amino acids would synergistically inhibit growth of major fungal pathogens. We screened 172 novel combinations against three phytopathogens (Rhizocto

SUBMITTER: Vallieres C 

PROVIDER: S-EPMC6186996 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature