Data set for characterization of TNF-α-inducible glycosphingolipids in vascular endothelial cells.

ABSTRACT: The data presented here pertain to a research article entitled "Structural characterization and dynamics of globotetraosylceramide in vascular endothelial cells under TNF-α stimulation" (Okuda et al., 2010). The present article provides additional structural and gene expression data for the characterization of a TNF-α-inducible glycosphingolipid, globotetraosylceramide (Gb4), in vascular endothelial cells. (i) Structural details of Gb4 in lipid raft-enriched cell membranes were determined by MALDI-TOF MS. These analyses identified Gb4 with very-long-chain fatty acids as the major molecular species in this fraction, and the expression levels of whole molecular species of Gb4 with different fatty acid structures in the membrane are uniformly upregulated by TNF-α stimulation. (ii) The express

SUBMITTER: Okuda T 

PROVIDER: S-EPMC6187094 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature