Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

ABSTRACT: Nuclear hormone receptors (NRs), such as retinoic acid receptors (RARs), play critical roles in vertebrate development and homeostasis by regulating target gene transcription. Their activity is controlled by ligand-dependent release of corepressors and subsequent recruitment of coactivators, but how these individual receptor modes contribute to development are unknown. Here, we show that mice carrying targeted knockin mutations in the corepressor Silencing Mediator of Retinoid and Thyroid hormone receptor (SMRT) that specifically disable SMRT function in NR signaling (SMRT^mRID), display defects in cranial neural crest cell-derived structures and posterior homeotic transformations of axial vertebrae. SMRT^mRID embryos show enhanced transcription of RAR targets including

SUBMITTER: Hong SH 

PROVIDER: S-EPMC6187131 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature