L-Serine-modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier.

ABSTRACT: Effective delivery of drug carriers selectively to the kidney is challenging because of their uptake by the reticuloendothelial system in the liver and spleen, which limits effective treatment of kidney diseases and results in side effects. To address this issue, we synthesized l-serine (Ser)-modified polyamidoamine dendrimer (PAMAM) as a potent renal targeting drug carrier. Approximately 82% of the dose was accumulated in the kidney at 3 h after i.v. injection of ¹¹¹In-labeled Ser-PAMAM in mice, while i.v. injection of ¹¹¹In-labeled unmodified PAMAM, l-threonine modified PAMAM, and l-tyrosine modified PAMAM resulted in kidney accumulations of 28%, 35%, and 31%, respectively. Single-photon emission computed tomography/computed tomography (SPECT/CT) images also indicat

SUBMITTER: Matsuura S 

PROVIDER: S-EPMC6187148 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature