The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation.

ABSTRACT: Multicellular organisms have well-defined, tightly regulated mechanisms for cell adhesion. Heterodimeric αβ integrin receptors play central roles in this function and regulate processes for normal cell functions, including signaling, cell migration, and development, binding to the extracellular matrix, and senescence. They are involved in hemostasis and the immune response, participate in leukocyte function, and have biological implications in angiogenesis and cancer. Proper control of integrin activation for cellular communication with the external environment requires several physiological processes. Perturbation of these equilibria may lead to constitutive integrin activation that results in bleeding disorders. Furthermore, integrins play key roles in cancer progression and metastasis i

SUBMITTER: Chinthalapudi K 

PROVIDER: S-EPMC6187153 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature