Versatility of multivalent orientation, inverted meiosis, and rescued fitness in holocentric chromosomal hybrids.

ABSTRACT: Chromosomal rearrangements (e.g., fusions/fissions) have the potential to drive speciation. However, their accumulation in a population is generally viewed as unlikely, because chromosomal heterozygosity should lead to meiotic problems and aneuploid gametes. Canonical meiosis involves segregation of homologous chromosomes in meiosis I and sister chromatid segregation during meiosis II. In organisms with holocentric chromosomes, which are characterized by kinetic activity distributed along almost the entire chromosome length, this order may be inverted depending on their metaphase I orientation. Here we analyzed the evolutionary role of this intrinsic versatility of holocentric chromosomes, which is not available to monocentric ones, by studying F₁ to F₄ hybrids betwee

SUBMITTER: Lukhtanov VA 

PROVIDER: S-EPMC6187165 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature