Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.

ABSTRACT: Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94 cochaperone that is expressed in marginal zone (MZ) B cells and during the terminal differentiation of B cells to antibody-secreting cells. By analyzing Mzb1^-/-Prdm1^+/gfp mice, we find that Mzb1 is specifically required for the differentiation and function of antibody-secreting cells in a T cell-independent immune response. We find that Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes. In addition, we find that Mzb1^-/- plasmablasts show a reduced activation of β

SUBMITTER: Andreani V 

PROVIDER: S-EPMC6187189 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature